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SALVAGENE NEWS

presented by PROF.DR. ROBERT HESS

PROF. ROBERT HESS: THE 3 DIMENSIONS OF THE GENETIC CODE

Along with the media and the general public around the world, we were fascinated by the publication of the human genome in 2001. The findings were revolutionary in their implications: not only are our genes unique but also the process by which we can maintain our health. There is an infallible method: Identifying the right way of living for our genetic predisposition. This involves a combination of data processing, biological sciences, nanotechnology and computerised proteomics that will allow new interventions (not always predictable in their consequences) in the development of homo sapiens, a species that is not the final stage of evolution but only an intermediate product along the way.

But it is not only the first genetic code that has such great influence on our health and wellbeing; the second code has probably a much more decisive say in how we age and what influences we have on this process. As a result of changing dietary habits and of permanent access to calories, the epigenetic regulatory mechanisms have changed, the insulinogenic ‘second messengers’ have been over-expressed and thus also the anthropomorphic parameters. And last but not least, our understanding of gestation, as more and more details become known of the signal molecules that are necessary in the critical development phases for certain organs. Prolactin and progesterone are typical examples. And here, science has been enriched by a new and fascinating area: after the decryption of the genetic code and after the exploration of the epigenetic function marking of our genome (a work still in progress), we are now turning to the decryption of the third code, namely that of gestation. Taking all of this together and adding the latest biochemical markers such as telomere lengths, it is now possible to develop a sophisticated individualised age prevention strategy, and that is precisely the target that we have set ourselves on behalf of each and every one of our clients.

The Telomere-Management Module

At the Amec exhibition in Paris last November, the Salvagene Group unveiled its latest module from the slow-aging range. We will be presenting this to you at the end of the month in the framework of the new Salvagene procedure model. The launch was preceded by a two-year test phase in partnership with the European Epigenetic Center and the University of Vienna which has now been successfully completed and culminated in official approval.

The new Telomere Management module from Salvagene focuses on the issues of slow aging and cancer prevention and is an absolute world first in its conception. In the field of telomere biology, it was the Salvagene Group and its partners who achieved a first by including telomere measurement as a standard feature of our PREMIUM product. This was shortly after our colleague Elizabeth Blackburn was awarded the Nobel Prize. It means that we now have the world’s largest telomere measurement database. This has added yet another important core competence to the Salvagen Group – the activation of telomerase by means of our latest generation of Telomerase Activator for slowing the aging process. This experience is now the basis for the new module.

Salvagene Telomere Management comprises three world firsts

1. EpiGenetic analysis

For the first time in telomere biology, four different gene segments with a high significance for cell division rate have been identified. Their epigenetic changes, for example by addition of methyl groups – also referred to as the epigenome – block reading of the gene and, depending on epigenetic change, can result in greatly increased cell division speeds and thus temporarily to major telomere shortening.

This discovery helps us to identify the main cause of pronounced telomere shortening and consequently of greatly accelerated aging and disease processes. The transparency it brings allows us to develop a highly effective and personalized telomere management strategy for our customers on a hitherto unprecedented scale.

2. Determination of telomere length

Our experience with telomere measurement going back over several years served as the basis for the latest development in the measurement of telomere length. The new measuring procedure developed jointly with the University of Vienna now allows our clients to conveniently take samples at home in the form of saliva swabs and capillary blood spot tests rather than venipuncture as was previously the case.
 
Another advantage is that the process is much more sensitive and can therefore detect even the smallest changes in telomere structure. This makes genuine and effective telomere monitoring possible for the first time anywhere in the world. Consequently, Salvagene recommends that measurements are carried out every four months to provide exceptionally effective prevention of premature aging and of cancer and to combat any cell change developments at as early a stage as possible. The risk of cancer increases exponentially with age. One reason is the decrease in cellular protection provided by tumor suppressor genes which are steadily “switched off” as part of the aging process. This is precisely what we aim to prevent. Put simply, we switch good genes back on again.

3. Personalized telomere therapy

In order to achieve just that, the results of the epigenetic telomere analysis are used to formulate a highly individualized plant-based recipe aimed at stimulating the client’s own telomerase to the maximum level possible, thereby delaying the biological aging process. The missing DNA segments in the cell are supplemented by the telomerase enzyme, causing the cell to regenerate.        

This is particularly beneficial to skin cells: the skin becomes firmer and fresher within a relatively short time. Furthermore, the degeneration of cell structures is reversed, thereby nipping oncological processes in the bud. The therapy also achieves this by reversing potential epigenetic changes with demethylation and greatly reducing the cell division rate.

The Salvagene Group is the world’s first health provider to offer a personalized telomerase activator.

The basis of this is the best[2] nine of the currently researched substances. The plants we use are organically cultivated in specially selected ecologically favorable growing areas at high altitude, including in Tibet. A basic requirement for the best plant-based nutrients is fertile, deep soil with a low CO2 air content. Also important is the micro fauna with its ideal pH, which further enhances the purity of the substances.

We pay special attention to the timing of the harvest, for example the epigallocatechin gallate (EGCG) which we get from the tips of green tea leaves over many weeks of harvesting. It is only in this way and with a gentle freeze-drying process that we can achieve sufficient purity and enrichment for our telomere therapy. Similar criteria apply to another substance – tocotrienol[3] – which is important for the re-activation of good genes.

The requisite quantity and purity can only be derived from wheat and barley grasses grown at high altitude. Crucial to success, namely the lengthening of telomeres, is the INDIVIDUAL combination of these nine substances based on your analysis results. Since telomere lengths and epigenetics are in a permanent state of change, the composition is continually adjusted on the basis of the analysis which takes place three times a year. Unlike with conventional telomerase activators, the individualized formulas and the use of exclusively natural substances ensure that only the telomeres of healthy cells are lengthened.

The personalized Salvagene Telomerase Activator

  • significantly increased telomerase activity
  • thereby lengthening telomeres
  • protects the DNA
  • prevents chromosomal instability (CIN)
  • delays the aging process
  • optimizes the Hayflick limit
  • supports the reactivation of senescent cells
  • prevents age-related diseases and oncological events
  • protects skin cells

 
 The success of the therapy is shown in transparent fashion by a telomere management report which is prepared for you every four months. This will include your current biological age and your measured speed of aging as well as an indication of how this has changed over time. You will also be able to see how much you have aged during the monitoring period.

 

The process is really straightforward. Sampling is carried out every four months in the comfort of your own home with a simple saliva swab and capillary blood spot test. Based on the result, a personalized telomerase[4] activator is produced and sent to you in the form of a granular powder. 
    
The analysis is performed at the latest addition to our group of Salvagene laboratories. This is actually a spin-off of the Medical University of Vienna. The laboratory is located on the campus of the Vienna General Hospital together with thirty other university clinics and clinical institutes.